interview with Professor Holčapek: Interdisciplinary Collaboration Is Absolutely Essential for Research in the Natural Sciences

Professor Michal Holčapek is among the most frequently cited scientists in the fields of mass spectrometry and lipidomics. In this interview, conducted after a networking event at the University of Pardubice, he emphasizes that cutting-edge research relies on interdisciplinary collaboration and the sharing of expertise. He speaks openly about the challenges of scientific evaluation and why researchers should focus on the essence of problems rather than on metrics.

7 Apr 2025 Lucie Skřičková

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Your work focuses on mass spectrometry and lipidomic analysis, particularly on identifying lipid biomarkers for early cancer detection. How important is data sharing and interdisciplinary collaboration in your research?

Interdisciplinary collaboration is absolutely essential for research in the natural sciences. Nowadays, no single laboratory can cover all the necessary areas of expertise. That’s why cooperation between analytical chemists, biologists, and medical professionals is crucial to achieving truly significant advances in research. As for complex data, each omics technique generates a specific data format. Through multi-omics integration, we attempt to connect these data and translate them into biologically meaningful conclusions. This is an exceptionally demanding and complex process.


Can the sharing and re-use of scientific data help accelerate the development of lipidomics and its application in modern medicine?

The re-use of previously acquired data is advantageous in that, although we may not be able to draw certain conclusions from them today, with future advancements in scientific disciplines and bioinformatics, those same datasets may yield new and valuable insights that are currently beyond our reach. This approach is summarized in the so-called FAIR principles for scientific data management and sharing.


You collaborate with researchers from Germany, Austria, Singapore, and other countries. How does data sharing work within these international collaborations? What are the biggest obstacles to effective data exchange?

Each country has a slightly different approach, but more important than national differences are the specific teams and their culture of collaboration. Trust between partners is key—if there’s trust, data is shared without issues. That said, it is common practice to formalize collaborations legally, for example, through NDAs (Non-Disclosure Agreement) or MTAs (Material Transfer Agreement).






“Reusing previously acquired data is advantageous because, with future advancements in scientific disciplines, those same datasets may yield new and valuable insights that are currently beyond our reach.”

In your view, how does the current system of scientific evaluation influence the direction of research?

In the current evaluation system, it’s no longer just about quantity and bibliometric indicators—which sometimes led certain teams to pursue unfortunate strategies, such as producing an excessive number of publications in predatory journals with questionable peer-review standards. Today, much greater emphasis is placed on the quality of the journal and the article itself. Evaluations also take into account the author’s position within the team, making it possible to assess a scientist’s contribution more objectively. Of course, no evaluation system is ever perfect, but based on my experience on panels of grant agencies such as the Czech Science Agency and the ERC, I can say there’s a strong effort to ensure fair and thorough assessments of both researchers and proposals. Scientists should strive to remain independent of evaluation mechanisms and focus instead on understanding and describing the core of the problem they are investigating, to the best of their ability.


Scientific publishing faces many challenges—from high publication fees to concerns about peer-review quality. What changes would you like to see in this system?

In the past, I considered the introduction of the Open Access model to be a major mistake, as it led to the proliferation of so-called predatory publishers and journals. These entities profit significantly from Open Access publication fees, often publishing work after insufficient or even completely dubious peer review. From my perspective, this represents one of the most serious issues and distortions in the scientific environment. I wish such a model had never been introduced—and now, I can only hope that the consequences of its implementation can be mitigated by emphasizing the importance of quality over quantity.


Open Science and data-sharing initiatives are increasingly connecting scientific communities across Europe. In your opinion, what impact does building shared data infrastructure have on research and international cooperation?

Sharing scientific information is clearly a way to use tax payers’ money more effectively and accelerate progress in science and research. What’s crucial is ensuring equal access for all scientists to these infrastructures so that researchers from prestigious institutions or countries are not disproportionately favored while others are left behind.





“Today, much greater emphasis is placed on the quality of the journal and the article itself. Evaluations also take into account the author’s position within the team, making it possible to assess a scientist’s contribution more objectively.”

prof. Ing. Michal Holčapek, Ph.D.


works at the Faculty of Chemical Technology at the University of Pardubice specializes in the use of mass spectrometry for the qualitative and quantitative analysis of organic and bioorganic compounds. A leading expert in mass spectrometry and lipidomics, his research plays a crucial role in the early detection of cancer. He collaborates with top research teams worldwide and participates in international projects. With over 160 publications, he is among the most influential and cited scientists in his field. His work has earned him numerous awards, including the Special Jury Prize of the Czech Brain and the Neuron Award 2023 for bridging science and business. He currently serves as Vice President of the International Lipidomics Society.


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